Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-05 05:16 am

Emergent Ventures winners, 50th cohort

Posted by Tyler Cowen

Geby Jaff, Berkeley, publication medium for AI-generated science.

Laura Ryan, London, data for the AIs.

Tara Rezaei, MIT, general career support/AI/o1.

Mihir Rao, Princeton, bio and AI.

Lorna MacLean, London, AI medical diagnosis of endometriosis.

David Yu, Waterloo, Ontario/Taiwan, fellowship program for agentic Taiwanese college students.

Aniket Panjwani, Lombard, Illinois, EconNow, AI-based software for economics.

Zixuan (Eric) Ma, GMU, to write about China.

Ivan Khalamendyk, Lviv, “I’m an independent Ukrainian physicist developing a ψ-field model of the universe – a single real wave ψ(x,t) that reproduces quantum matter, forces and gravity.”

José Luis Sabau, Mexico City, Perpetuo, Substack for Mexico.

Soleil Wizman, Yale University, longevity.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-04 07:38 pm

Abu Dhabi fact of the day

Posted by Tyler Cowen

International Holding Company has been growing:

IHC’s $240bn market capitalisation makes it by far the biggest constituent of the Abu Dhabi stock exchange, taking up 41.5 per cent of the FTSE ADX General Index — a figure that rises still further when listed subsidiaries such as Alpha Dhabi and 2PointZero are included.

First Abu Dhabi Bank, the country’s largest lender and runner-up at a 10 per cent weighting, is also chaired by Sheikh Tahnoon. Because IHC is ultimately controlled by Sheikh Tahnoon, who is also the UAE’s national security adviser and chairs two of Abu Dhabi’s sovereign wealth funds, academics classify it as a “state-related entity”.

IHC in turn consists of about 1500 firms, though consolidation is promised.  Here is the full FT article.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-04 12:18 pm

Innovations in Health Care

Posted by Alex Tabarrok

The latest issue of the journal Innovations focuses on health care and is excellent. It’s a very special issue–a double Tabarrok issue!

My paper, Operation Warp Speed: Negative and Positive Lessons for New Industrial Policy, asks what can learn from the tremendous success of OWS about an OWS for X? What are the opportunities and the dangers?

My son Maxwell Tabarrok’s paper is Peptide-DB: A Million-Peptide Database to Accelerate Science. Max’s paper combines economics and science policy. Open databases are a public good and so are underprovided. A case in point is that there is no big database for anti-microbial peptides despite the evident utility of such a database for using ML techniques to create new antibiotics. The NIH and other organizations have successfully filled this gap with databases in the past such as PubChem, the HGP, and ProteinDB. A million-peptide database is well within their reach:

The existing data infrastructure for antimicrobial peptides is tiny and scattered: a few thousand sequences with a couple of useful biological assays are scattered across dozens of data providers. No one in science today has the incentives to create this data. Pharma companies can’t make money from it and researchers can’t produce any splashy publications. This means that researchers are duplicating the expensive legwork of collating and cleaning all of this
data and are not getting optimal results, as this is simply not enough information to take full advantage of the ML approach. Scientific funding organizations, including the NIH and the NSF, can fix this problem. The scientific knowledge required to massively scale the data we have on antimicrobial peptides is well established and ready to go. It wouldn’t be too expensive or take too long to get a clean dataset of a million peptides or more, and to have detailed information on their activity against the most important resistant pathogens as well as its toxicity to human cells. This is well within the scale of the successful projects these organizations have funded in the past, including PubChem, the HGP, and ProteinDB.

Naturally, I am biased towards Tabarrok-articles but another important paper is Reorganizing the CDC for Effective Public Health Emergency Response by Gowda, Ranasinghe, and Phan. As Michael Lewis wrote in The Premonition by the time of COVID the CDC had became more akin to an academic department than a virus fighting agency:

The CDC did many things. It published learned papers on health crises, after the fact. It managed, very carefully, public perception of itself. But when the shooting started, it leapt into the nearest hole, while others took fire.

Gowda, Ranasinghe, and Phan agree.

The COVID-19 pandemic revealed significant weaknesses in the CDC’s response system. Its traditional strengths in testing, pathogen dentification, and disease investigation and tracking faltered. The legacy of Alexander Langmuir, a pioneering epidemiologist who infused the CDC with epidemiological principles in the 1950s, now seems a distant memory. Tasks as basic as collecting and providing timely COVID-19 data, along with data analysis and epidemiological modeling—both of which should have been the core capability of the CDC—became alarmingly difficult and had to be handled by nongovernmental organizations, such as the Johns Hopkins University Coronavirus Resource Center.

A closer examination of the CDC’s workforce composition reveals the root cause: a mere fraction of its employees are epidemiologists and data scientists. The agency has seen an increasing emphasis on academic exploration at the expense of on the-ground action and support for frontline health departments. (Armstrong & Griffin, 2022).

The authors propose to reinvigorate the CDC by integrating it with the more practical and active U.S. Public Health Service. This is a very good suggestion.

For one more check out Bai, Hyman and Silver as a primer on Improving Health Care. The entire issue is excellent.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-04 06:27 am

My Conversation with the excellent Dan Wang

Posted by Tyler Cowen

Here is the audio, video, and transcript.  Here is part of the episode summary:

Tyler and Dan debate whether American infrastructure is actually broken or just differently optimized, why health care spending should reach 35% of GDP, how lawyerly influences shaped East Asian development differently than China, China’s lack of a liberal tradition and why it won’t democratize like South Korea or Taiwan did, its economic dysfunction despite its manufacturing superstars, Chinese pragmatism and bureaucratic incentives, a 10-day itinerary for Yunnan, James C. Scott’s work on Zomia, whether Beijing or Shanghai is the better city, Liu Cixin and why volume one of The Three-Body Problem is the best, why contemporary Chinese music and film have declined under Xi, Chinese marriage markets and what it’s like to be elderly in China, the Dan Wang production function, why Stendhal is his favorite novelist and Rossini’s Comte Ory moves him, what Dan wants to learn next, whether LLMs will make Tyler’s hyper-specific podcast questions obsolete, what flavor of drama their conversation turned out to be, and more.

Excerpt:

COWEN: When will Chinese suburbs be really attractive?

WANG: What are Chinese suburbs? You use this term, Tyler, and I’m not sure what exactly they mean.

COWEN: You have a yard and a dog and a car, right?

WANG: Yes.

COWEN: You control your school district with the other parents. That’s a suburb.

WANG: How about never? I’m not expecting that China will have American-style suburbs anytime soon, in part because of the social engineering projects that are pretty extensive in China. I think there is a sense in which Chinese cities are not especially dense. Indian cities are much, much more dense. I think that Chinese cities, the streets are not necessarily terribly full of people all the time. They just sprawl quite extensively.

They sprawl in ways that I think the edges of the city still look somewhat like the center of the city, which there’s too many high-rises. There’s probably fewer parks. There’s probably fewer restaurants. Almost nobody has a yard and a dog in their home. That’s in part because the Communist Party has organized most people to live in apartment compounds in which it is much easier to control them.

We saw this really extensively in the pandemic, in which people were unable to leave their Shanghai apartment compounds for anything other than getting their noses and mouths swabbed. I write a little bit about how, if you take the rail outside of major cities like Beijing and Shanghai, you hit farmland really, really quickly. That is in part because the Communist Party assesses governors as well as mayors on their degree of food self-sufficiency.

Cities like Shanghai and Beijing have to produce a lot of their own crops, both grains as well as vegetables, as well as fruits, as well as livestock, within a certain radius so that in case there’s ever a major devastating war, they don’t have to rely on strawberries from Mexico or strawberries from Cambodia, or Thailand. There’s a lot of farmland allocated outside of major cities. I think that will prevent suburban sprawl. You can’t control people if they all have a yard as well as a dog. I think the Communist Party will not allow it.

COWEN: Whether the variable of engineers matters, I went and I looked at the history of other East Asian economies, which have done very well in manufacturing, built out generally excellent infrastructure. None of these problems with the Second Avenue line in New York. Taiwan, like the presidents, at least if we believe GPT-5, three of them were lawyers and none of them were engineers. South Korea, you have actually some economists, a lot of bureaucrats.

WANG: Wow. Imagine that. Economists in charge, Tyler.

COWEN: I wouldn’t think it could work. A few lawyers, one engineer. Singapore, Lee Kuan Yew, he’s a lawyer. He thinks in a very lawyerly manner. Singapore has arguably done the best of all those countries. Much richer than China, inspired China. Why should I think engineers rather than just East Asia, and a bunch of other accompanying facts about these places are what matter?

WANG: Japan, a lot of lawyers in the top leadership. What exactly was the leadership of Hong Kong? A bunch of British civil servants.

COWEN: Some of whom are probably lawyers or legal-type minds, right? Not in general engineers.

WANG: PPE grads. I think that we can understand the engineering variable mostly because of how much more China has done relative to Japan and South Korea and Taiwan.

COWEN: It’s much, much poorer. Per capita manufacturing output is gone much better in these other countries.

And:

WANG: Tyler, what does it say about us that you and I have generally a lot of similar interests in terms of, let’s call it books, music, all sorts of things, but when it comes to particular categories of things, we oppose each other diametrically. I much prefer Anna Karenina to War and Peace. I prefer Buddenbrooks to Magic Mountain. Here again, you oppose me. What’s the deal?

COWEN: I don’t think the differences are that big. For instance, if we ask ourselves, what’s the relative ranking of Chengdu plus Chongqing compared to the rest of the world? We’re 98.5% in agreement compared to almost anyone else. When you get to the micro level, the so-called narcissism of petty differences, obviously, you’re born in China. I grew up in New Jersey. It’s going to shape our perspectives.

Anything in China, you have been there in a much more full-time way, and you speak and read Chinese, and none of that applies to me. I’m popping in and out as a tourist. Then, I think the differences make much more sense. It’s possible I would prefer to live in Shanghai for essentially the reasons you mentioned. If I’m somewhere for a week, I’m definitely going to pick Beijing. I’ll go around to the galleries. The things that are terrible about the city just don’t bother me that much, because I know I’ll be gone.

WANG: 98.5% agreement. I’ll take that, Tyler. It’s you and me against the rest of the world, but then we’ll save our best disagreements for each other.

COWEN: Let’s see if you can pass an intellectual Turing test. Why is it that I think Yunnan is the single best place in the world to visit? Just flat out the best if you had to pick one region. Not why you think it is, but why I think it is.

Strongly recommended, Dan and I had so much fun we kept going for about an hour and forty minutes.  And of course you should buy and read Dan’s bestselling book Breakneck: China’s Quest to Engineer the Future.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-03 08:11 pm

The importance of the internet

Posted by Tyler Cowen

From my recent chat with Alex, mostly about fiscal policy:

TABARROK:To be clear, a 0.5% increase in the rate of productivity growth, that doesn’t seem like a lot, but that would be historically a bigger increase than we got from anything. A bigger increase than the internet. Sure, yes.

COWEN:It is the internet in a way, but yes.

TABARROK:It was founded on the internet, yes. The internet was the agar culturefor the growth of the AI.

COWEN:That’s why the internet’s important. We’re just beginning to realize this,right?

TABARROK:Exactly, yes.

COWEN:It’s why a lot of people can’t admit AI might be a good thing, because then they’d have to admit the internet was a good thing. They’re so committed to never saying that.

TABARROK:Is that why?

COWEN:That’s why, yes.Believe me. That’s why.

TABARROK:It is funny that I think historically, when we look back, I think you’re right, we’ll think about what was the internet. The growth culture was putting everything online, was for the AI. It wasn’t for us.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-03 12:17 pm

The MR Podcast: Debt!

Posted by Alex Tabarrok

On The Marginal Revolution Podcast this week, Tyler and I discuss the US debt. This is our final podcast of the year. Here’s one bit:

TABARROK: I do agree that it is puzzling that the interest rate on bonds is so low. Hanno Lustig and his co-authors have an interesting paper on this. They point out that not only is it the case that we have all of this debt with no plans to pay it, as far as we can tell right now, but the debt is not a very good asset in the sense that when will the debt be paid? If it is going to be paid, it’s going to be paid when the times are good. That means that you’re being paid when GDP is higher and the marginal utility money is low.

When is the debt not paid? When does it get bigger? It means when the economy is doing poorly. The debt as an asset has the opposite kind of structure than you would want. It’s not like gold, which arguably goes down in good times and goes up in bad times. You get some nice covariance to even out your portfolio. The debt as an asset is positively correlated with good times, and that’s bad. You should expect the interest rates to be much, much higher than they actually are.

COWEN: The easy out there is just to say it’s always going to be paid. Let me give you a way of reconceptualizing the problem. The Hanno Lustig paper, which is called “US Public Debt Valuation Puzzle,” like a lot of work on debt, it focuses on flows. There’s the rate of interest, there’s government spending. If you look at stocks, look at the stock of wealth in the United States. A common estimate from the past was wealth is six to eight times higher than GDP. That’s a little misleading. How do you value all the wealth? How liquid is it?

Still, we all know there’s a lot more wealth than GDP. If your economy stays at peace, if anything, that ratio rises. You build things, they’re pretty durable. None of it is destroyed by bombs. We’re just headed to having more and more wealth. If you take, say, 100% debt-to-GDP ratio, and you think wealth is six to eight times higher, what’s our debt-to-wealth ratio? Well, it’s going to depend what kind of wealth, how liquid, blah, blah, blah. Let’s say it’s like 20%. Let’s say you had a debt ratio of 20% to your wealth at some point in the history of your mortgage. I bet you did. You weren’t worried. Why should the US be worried?

TABARROK: The US is a much longer-lived entity, presumably, than I am.

COWEN: That’s right. You could have 200% debt-to-GDP ratio. In terms of your debt-to-wealth ratio, again, it’s somewhat arbitrary, but say it’s 40% to 50% that might be on the high side. It’s not pleasant, but I’ve been in that situation with mortgages.

Here’s the episode. Subscribe now to take a small step toward a much better world: Apple Podcasts | Spotify | YouTube.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-03 05:34 am

Congressional leadership is corrupt

Posted by Tyler Cowen

Using transaction-level data on US congressional stock trades, we find that lawmakers who later ascend to leadership positions perform similarly to matched peers beforehand but outperform them by 47 percentage points annually after ascension. Leaders’ superior performance arises through two mechanisms. The political influence channel is reflected in higher returns when their party controls the chamber, sales of stocks preceding regulatory actions, and purchase of stocks whose firms receiving more government contracts and favorable party support on bills. The corporate access channel is reflected in stock trades that predict subsequent corporate news and greater returns on donor-owned or home-state firms.

That is from a new NBER working paper by Shang-Jin Wei and Yifan Zhou.  Of course Alex T. has been on this issue for a long time now.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-03 05:05 am

Pharma supply is elastic

Posted by Tyler Cowen

The crux of the problem is that the IRA imposes price caps that shorten the effective life of a patent and applies those price controls even to later-approved uses. Thirteen years after FDA approval, biologics, which are typically infused or injected, become subject to price controls. For small-molecule drugs, typically pills or tablets, the window is only nine years. The clock starts at a drug’s first approval, leaving a follow-on or alternative use, approved years later, an insufficient period to make up the cost of research.

Two weeks ago, a study I conducted with colleagues at the University of Chicago appeared in Health Affairs. It reveals how much these provisions harm cancer research. In reviewing every Food and Drug Administration-approved cancer drug between 2000 and 2024, we found a large part of innovation in cancer treatment takes place after a therapy is first approved. About 42% of the 184 cancer therapies that were initially approved during that period had follow-on approvals—involving new uses or “indications” for an existing drug—such as treating additional cancer types or being used earlier in the disease, when treatment outcomes tend to be better.

This cumulative progress through follow-on discoveries is a big driver of new cancer treatments, the largest drug class making up about 35% of the overall FDA pipeline. Cancer drugs are generally first tested in patients with late-stage disease, after which the drug is studied for use in earlier stages of that cancer and for new uses, including treating other cancers. Our study found that 60% of follow-on drugs treated earlier stages than the initial drugs. This is important because treating earlier stages is often more successful than when a cancer has spread more.

But that cumulative progress depends on incentives for sustained research well after the first FDA approval—often years of additional trials and investments. And those incentives were killed by the IRA.

Here is more by Tomas J. Philipson from the WSJ.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-02 05:55 pm

The Dells add to Trump Accounts

Posted by Alex Tabarrok

I wrote that Trump Accounts Are A Big Deal. These accounts give U.S. citizen’s born between January 1, 2025, and December 31, 2028, $1000 invested in a low-cost, diversified U.S. stock index fund. Well, the accounts just got bigger. Michael and Susan Dell are donating $6.25 billion to seed accounts with $250 for children born before Jan. 2025, up to ten years of age:

The Dells have committed to seed Trump accounts with $250 for children who are 10 or under who were born before Jan. 1, 2025. According to Invest America, the pledged funds will cover 25 million children age 10 and under in ZIP codes with a median income of $150,000 or less.

“We want to help the children that weren’t part of the government program,” Dell said.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-02 05:10 pm

Tuesday assorted links

Posted by Tyler Cowen

1. Brangus on women, the incels need this, noting I do not agree with all the points.  But better than the PUA stuff.

2. The monarchy returns in Tonga.

3. Hail the Swiss.  80 percent rejection.  And Johann notes to me: “Only two municipalities voted yes on the recent ballot measure for a 50% inheritance tax over 50 million francs: The city of Bern with about 140’000 inhabitants and the village of Schelten with 34.”

4. Woman on a mission to photograph every species of hummingbird.

5. Parties of the Right rising in Honduras, party of the Left plummeting.  But when will the ruling party resume the count or make the count public?  And it seems the two leading candidates are both ethnically Palestinian?

6. Why many people have trouble with the concept of strong AI or AGI.

7. Is the Mississippi reading miracle in part statistical illusion?

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-02 12:17 pm

The People’s Republic of Santa Monica

Posted by Alex Tabarrok

Here’s a video from real estate investor and youtuber Graham Stephan. He’s explaining (starting at 7:23) why he is selling a home in Santa Monica instead of renting it out–it’s the rent control laws, of course. The laws are strongly biased against landlords. Perhaps landlords should be a protected class.

Everything he says about the law, by the way, is accurate. I was initially skeptical (as was Google Gemini) that homes had to be rented unfurnished. Why would that stupidity be a law? But no, it’s accurate. Apparently, the idea is to make it more difficult to rent to temporary residents.

To preserve rental housing for permanent residents, all rental units must be rented unfurnished for an initial term of not less than one year and only to natural persons intending to use the unit as their primary residence.

Here’s Google Gemini summarizing, once I corrected it on the unfurnished home law.

The speaker’s understanding of the Santa Monica Rent Control and Just Cause laws is highly accurate in almost all respects:

  1. Subject to Rent Control (7:50): Accurate. A non-primary residence built before 1979 is typically subject to the law.

  2. Indefinite Tenancy (8:50): Accurate. Tenants gain “permanent right” to occupancy as eviction is limited to specific “just causes.”

  3. Rent Increase Limit ($60/AGI) (8:13): Accurate. The annual rent increase is capped by a fixed, low dollar amount (the AGI), which closely aligns with the speaker’s figure.

  4. No Eviction to Sell (8:57): Accurate. Selling the property is not a “just cause” for eviction.

  5. Owner Move-In (OMI) Requirements (9:14):Accurate. Eviction for OMI requires paying substantial relocation fees, re-offering the unit if re-rented within two years, and prohibits eviction during the school year.

  6. Furnished Home Prohibition (9:56):Accurate. Santa Monica requires rental units to be initially rented unfurnished to permanent residents.

Hat tip: Naveen Nvn who also says this video is worth watching.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-02 09:03 am

The myth of the $140,000 poverty line

Posted by Tyler Cowen

That is my latest piece for The Free Press, focusing on the claims of Michael W. Green.  Excerpt:

Most of all, there is a major conceptual error in Green’s focus on high prices. To the extent that prices are high, it is not because our supply chains have been destroyed by earthquakes or nuclear bombs. Rather, prices are high in large part because demand is high, which can only happen because so many more Americans can afford to buy things. I am reminded of the old Yogi Berra saying: “Nobody goes there anymore. It’s too crowded.”

There are now numerous excellent criticisms of the same piece, for instance by Scott Winship and Noah Smith.  As my piece was in the works, Green published this response to some of the criticisms.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-02 05:23 am

Séb Krier

Posted by Tyler Cowen

Huge fan of multi agent systems, agent based modelling, and social intelligence – these frames still seem really absent from mainstream AI discourse except in a few odd places. Some half-baked thoughts:

1. Expecting a model to do all the work, solve everything, come up with new innovations etc is probably not right. This was kinda the implicit assumption behind *some* interpretations of capabilities progress. The ‘single genius model’ overlooks the fact that inference costs and context windows are finite.

2. People overrate individual intelligence: most innovations are the product of social organisations (cooperation) and market dynamics (competition), not a single genius savant. Though the latter matters too of course: the smarter the agents the better.

3. There’s still a lot of juice to be squeezed from models, but I would think it has more to do with how they’re organised. AI Village is a nice vignette, and also highlights the many ways in which models fail and what needs to be fixed.

4. Once you enter multi-agent world, then institutions and culture start to matter too: what are the rules of the game? What is encouraged vs what is punished? What can agents do and say to each other? How are conflicts resolved? It’s been interesting seeing how some protocols recently emerged. We’re still very early!

5. Most of the *value* and transformative changes we will get from AI will come from products, not models. The models are the cognitive raw power, the products are what makes them useful and adapted to what some user class actually needs. A product is basically the bridge between raw potential and specific utility; in fact many IDEs today are essentially crystallized multi agent systems.

Here is the link.

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Marginal Revolution ([syndicated profile] marginal_revolution_feed) wrote2025-12-01 08:35 pm

*Liberal Worlds: James Bryce and the Democratic Intellect*

Posted by Tyler Cowen

By H.S. Jones, an excellent book.  For all the resurgence of interest in government and its problems, Bryce has received remarkably little attention.  But his theory of low-quality, careerist politcians, combined with imperfectly informed voters, seems highly relevant to our current day.  Public opinion is slow, and largely reactive, but potent once mobilized.  Leadership can truly matter, and he stresses national character and civic education.  In other words, Bryce’s The American Commonwealth is a book still worth reading.

I had not known that Bryce was born in Belfast, or that he was so opposed to women’s suffrage.  Or that he was so interested in Armenia, climbed Mount Ararat, and was fascinated by the inevitability of interracial marriage and its consequences (no, not in the usual racist way).  He was an expert on Roman law.

Recommended, and also very well written.

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